Topical and oral medications custom curated by your dermatologist.

Explore our treatments

Apostrophe Custom Topical Formula

$75 for a 90 day supply

5.00/5 based on 0 reviews

Our proprietary custom topical formula comes packed with prescription-grade ingredients in a moisturizing lotion with 4% niacinamide, aloe and vitamin E. Apostrophe’s topical medication blends seamlessly into your skincare routine– no more weird goopy aluminum tubes. All that tailored to you by your board-certified dermatologist.

The ingredients

The fundamentals of your topical treatment

We don’t skimp on efficacy, ever. Apostrophe is rated the most effective acne treatment* by consumers for a reason. We offer the widest range of prescription ingredients and strengths so our doctors can create the formula that’s perfect for your skin. From the most sensitive skin to the most severe acne, our custom topical formula has you covered.

*Based on a survey of 665 Apostrophe patients.

Acne treatment you'll want to use.

Our nourishing texture makes this prescription treatment blend seamlessly into your skincare routine, unlike goopy generics.

Apostrophe Oral Medications

$45-$90 for a 90 day supply

5.00/5 based on 0 reviews

Kickstart your acne treatment with oral medications. Apostrophe offers multiple kinds of antibiotic treatments that target acne-causing inflammation and hormonal acne treatments that can clear stubborn jawline acne in women.

Your clear skin
secret
weapon.

Orals are a powerful way to treat stubborn breakouts and hormonal acne. Think of them as your topical treatment’s partner in crime.

Antibiotics

These medications are typically short course treatments that help get your acne under control quicker. Your doctor will only prescribe these if they feel you’ll get better results.

Learn more about our antibiotics

Hormonal treatment

This treatment is for women who experience jawline breakouts that are caused by hormonal imbalances. Your doctor will only prescribe this if they feel you’re a good candidate.

Learn more about our hormonal treatments

Better, together.

Your Apostrophe treatment plan may contain several of these power-packed medications. Your dermatologist will design your medication to work synergistically together so you can get the best possible outcomes.

“Acne medications work best in combination since we’re able to fight acne from different angles. Only topical treatments target the root cause of acne, the clogged pore, but oral medications can quickly reduce inflammation to kickstart rapid improvement.”

Aimee paik, md

Real Patients,
real results.

Read reviews of our topical and oral medications below.

5.00/5 based on 5 reviews.
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445 reviews
1/12/2021

I am having really amazing results with this formula. I was scared to use tretinoin because I have sensitive skin but it has caused no irritation and my blackheads are gone! I tried everything for years and this is the only thing that has helped!

Antonia
1/12/2021
1/11/2021

Helping to clear up the sensitive acne spots that pop up from mask wear, ppe at work (healthcare), and pre-period hormonal changes. This was exactly what I needed. Something to prevent breakouts and treat spots that pop up. It definitely dries out the skin so moisturizing is super important. What a wonderful company, so quick to respond and meet your needs in a time where insurance and in person visits are complicated and drawn out!

Rachel
1/11/2021
1/9/2021

I have started using Tretinoin and the results are beginning to be visible. The effects are gentle, and there is very minimal peeling. I would recommend.

Irene
1/9/2021
1/6/2021

I'm only about a month into using this, so I'm still waiting to see an improvement. My understanding of Tretinoin is that it's a long game, with improvement coming several months (if not longer) after the initial start. So, I'm still waiting, but I have high hopes. I believe right now my skin is "purging" as I've been getting pimples in areas that are normally clear. Since this seems to be normal for Tret, I'm waiting it out and sticking with it. Results TBD!

Emily
1/6/2021
1/6/2021

So far so good! There was a "purge" period where I broke out kind of bad (but could have also been due to pms). Since those pimples healed, my skin has been very calm! I noticed the azelaic acid reduced the post acne spots very fast, even faster than my prescription retinoid cream with far less irritation. I'm really looking forward to seeing how my skin will look in a few more months of using this cream.

Carlie
1/6/2021
1/5/2021

I have used OTC clindamycin creams in the past, and they slightly worked, but with Apostrophe's formula that mixes clindamycin with benzoyl peroxide, my acne is clearing up within days instead of weeks! It's amazing!

Kaylee
1/5/2021
1/5/2021

I received my tretinoin formula a little over a week ago, and I can already see improvements in the texture and dark spots on my face! Compared to other topicals I've used in the past, tretinoin has definitely supplied better results!

Kaylee
1/5/2021
1/1/2021

I have tried many creams, lotions, spot treatments, from Proactive to drug store products, and this is the BEST! In two weeks of continued use my face is now clear! No new acne at all. I still have acne scars from many years of horrible acne but that is going to require a separate product, possible Retinol. Overall, this product delivers what it promises.

Angelica
1/1/2021
12/31/2020

I really love the product and the packaging with the stickers was so awesome. The product already began working after a week as well.

Timothy
12/31/2020
12/30/2020

It has been nearly a month since I began taking Spiro and my skin looks great. My skin was dry at first, but with proper water intake, it's much better. I noticed I feel lightheaded on days when I forget to take it at my usual time, but that's my fault and not the medication. Other than mild lightheadedness, I haven't felt symptoms. I will continue to use this medication and see its improvements.

Erin
12/30/2020