SpironolactoneA topical and oral medication that targets hormonal factors.SpironolactoneTopical & Oral MedicationTrueWomen who are pregnant should not use this medication.tabletpotassium-sparing diureticsPrescription25, 50, 100mg

Spironolactone for the treatment of acne in women, a retrospective study of 110 patients

International Journal of Women's Dermatology

In a retrospective study, spironolactone at doses between 100-200 mg/day was effective for most patients.

`

Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris

Journal of Clinical and Aesthetic Dermatology

A review article that discusses acne in post-adolescent females and use of spironolactone in this population.

`

Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial

Journal of Dermatological Treatment

Topical spiro reduced total acne lesion counts.

`

Anti-androgenic Therapy Using Oral Spironolactone for Acne Vulgaris in Asians

Aesthetic Plastic Surgery

Spironolactone 200 mg daily resulted in excellent improvement in most patients; no lab abnormalities were seen in the subset of patients who were tested.

`

Low-dose adjunctive spironolactone in the treatment of acne in women: A retrospective analysis of 85 consecutively treated patients

Journal of the American Academy of Dermatology

Spironolactone at doses of 50 to 100 mg daily resulted in improvement in 93% of patients, ranging from partial improvement to complete clearance.

`

Topical Spironolactone Reduces Sebum Secretion Rates in Young Adults

The Japanese Journal of Dermatology

Topical 5% spiro gel decreased oil production at 12 weeks without any local side effects.

`

Oral and topical spironolactone therapies in skin androgenization.

Europe PMC

Topical spiro seems to be effective without systemic side effects. Local side effects were few and mild.

`

Experience in the therapy of acne with topical administration of spironolactone as an antiandrogen

Europe PMC

Spiro was effective for treating acne after one month in this observational study (95% experienced improvement).

`

Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris.

Europe PMC

Topical spiro competes with the binding of DHT at DHT receptors in sebaceous gland and acts as an antiandrogen. When applied to large areas, no side effects were seen.

`

Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature.

British Journal of Dermatology

Common side effects of spironolactone include increased urination, headache, fatigue, dizziness, menstrual irregularities, breast tenderness, nausea, vomiting, stomach pain and rash. Serious side effects may include irregular heart rate, little/no urination, and muscle pain/weakness. Allergic reaction to this medication is rare. Symptoms of an allergic reaction include rash, itching/swelling (especially of face/tongue/throat), dizziness and trouble breathing. Spironolactone can cause severe birth defects. This medication should not be used by women who are pregnant, may become pregnant, or are at a high risk of pregnancy.

`

IngredientsSpironolactone

Spiro

Topical & Oral Medication

C24H32O4S

Oral medication icon clear backgroundBlack, pill shaped outline with white background.
Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

TARGETS:

AcneVarious circles filled in black and white used to represent a digital version of hormonal acne.

Hormonal causes of acne

Oil iconTwo tear drop shaped blasck outlines with additional circles and triangles withing representing texture on a white background.

Oil production

BENEFITS:

Improves moderate-to-severe acne and rosacea in adult women

Reduces acne located on the chest and back

Reduces cyclical hormonal flares

Decreases oily skin

2017

Spironolactone for the treatment of acne in women, a retrospective study of 110 patients

...

International Journal of Women's Dermatology

2012

Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris

Journal of Clinical and Aesthetic Dermatology

2010

Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial

...

Journal of Dermatological Treatment

2006

Anti-androgenic Therapy Using Oral Spironolactone for Acne Vulgaris in Asians

...

Aesthetic Plastic Surgery

2000

Low-dose adjunctive spironolactone in the treatment of acne in women: A retrospective analysis of 85 consecutively treated patients

...

Journal of the American Academy of Dermatology

1996

Topical Spironolactone Reduces Sebum Secretion Rates in Young Adults

The Japanese Journal of Dermatology

1990

Oral and topical spironolactone therapies in skin androgenization.

Europe PMC

1990

Experience in the therapy of acne with topical administration of spironolactone as an antiandrogen

...

Europe PMC

1988

Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris.

...

Europe PMC

1984

Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature.

...

British Journal of Dermatology

Horizontal scroll arrowsTwo black arrows facing opposite directions on top of one another to signify the ability to scroll left and right.

SIDE EFFECTS


Common side effects of spironolactone include increased urination, headache, fatigue, dizziness, menstrual irregularities, breast tenderness, nausea, vomiting, stomach pain and rash. Serious side effects may include irregular heart rate, little/no urination, and muscle pain/weakness. Allergic reaction to this medication is rare. Symptoms of an allergic reaction include rash, itching/swelling (especially of face/tongue/throat), dizziness and trouble breathing. Spironolactone can cause severe birth defects. This medication should not be used by women who are pregnant, may become pregnant, or are at a high risk of pregnancy.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Recommended Posts

A winning combination: oral + topical treatment
skin,acne,medication,science,patient care

2021-05-18T23:35:53.401Z

Apostrophe

A winning combination: oral + topical treatment

Read

Right arrowRight facing black arrow to indicate a scroll to the next item.
Prescription vs. OTC: acne treatment
acne,skincare,prescription,over-the-counter,ingredients,science

2020-01-22T21:20:54.250Z

Apostrophe

Prescription vs. OTC: acne treatment

Read

Right arrowRight facing black arrow to indicate a scroll to the next item.
Doxycycline: an antibiotic for acne
acne,science,antibiotics,skin,pharmamcy,advice

2020-01-22T21:07:07.045Z

Apostrophe

Doxycycline: an antibiotic for acne

Read

Right arrowRight facing black arrow to indicate a scroll to the next item.
Horizontal scroll arrowsTwo black arrows facing opposite directions on top of one another to signify the ability to scroll left and right.