Azelaic AcidOne topical with multiple benefits.Azelaic AcidTopical MedicationTruecreamdicarboxylic acidsPrescription15%

Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne.

Acta Derma Venerol

Treatment with azelaic acid 20% cream, compared to placebo, significantly reduced inflamed lesions after 1 month and non-inflamed lesions after 2 months. It also significantly reduced follicular propionibacterium density after 2 months.

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Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin.

Acta Derma Venerol

Azelaic acid 20% cream was significantly more effective than its vehicle at reducing acne after 3 months. Azelaic acid 20% cream was equally as effective as tretinoin 0.05% in reducing comedonal acne and overall response, however it was better tolerated with fewer side effects.

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Randomized, phase III, double-blind, vehicle-controlled clinical trial to evaluate the safety and efficacy of 12 weeks of twice-daily azelaic acid foam, 15% in papulopustular rosacea

Journal of the American Academy of Dermatology

Twice daily use of azelaic acid foam showed statistically significant decreases in lesion count and greater overall improvement over vehicle. Adverse effects were mild to moderate and resolved by the end of the study.

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Postinflammatory hyperpigmentation: A comprehensive overview

Journal of the American Academy of Dermatology

Azelaic acid 15% gel twice daily significantly reduced acne-induced post-inflammatory hyperpigmentation (PIH) in dark-skinned patients after 16 weeks. Azelaic acid 20% cream, compared to its vehicle, significantly reduced melasma and post-inflammatory hyperpigmentation after 24 weeks.

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Systematic review of rosacea treatments.

Journal of the American Academy of Dermatology

Azelaic acid is more effective than placebo in improving rosacea.

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Multiple mechanisms of action of azelaic acid: New findings

Journal of the American Academy of Dermatology

Azelaic acid has antiinflammatory, antimicrobial, and antikeratinizing effects.

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Combination azelaic acid therapy for acne vulgaris.

Journal of the American Academy of Dermatology

Azelaic acid is more effective when combined with other medications such as topical benzoyl peroxide 4% gel, clindamycin 1% gel, tretinoin 0.025% cream, and eythromycin 3%/benzoyl peroxide 5% gel.

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IngredientsAzelaic Acid

Azela

Topical Medication

C9H16O4

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

TARGETS:

Inflammation IconBlack like with a bump in the middle and a copy of that bump offset above the line.

Inflammation

AcneVarious circles filled in black and white used to represent a digital version of hormonal acne.

Acne-causing bacteria

Rosacea IconArray of same sized black circles on a white background.

Pigment Production

Non-Comedogenic IconBlack line with a circle shaped dip in the middle. Three black outlined circles float above.

Clogged pores

BENEFITS:

Improves moderate-to-severe rosacea

Reduces inflammatory and non-inflammatory acne lesions (i.e. reduces pimples and blackheads)

Lightens melasma

Reduces post-inflammatory hyperpigmentation

1989

Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne.

...

Acta Derma Venerol

1989

Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin.

...

Acta Derma Venerol

2015

Randomized, phase III, double-blind, vehicle-controlled clinical trial to evaluate the safety and efficacy of 12 weeks of twice-daily azelaic acid foam, 15% in papulopustular rosacea

...

Journal of the American Academy of Dermatology

2017

Postinflammatory hyperpigmentation: A comprehensive overview

Journal of the American Academy of Dermatology

2007

Systematic review of rosacea treatments.

Journal of the American Academy of Dermatology

2009

Multiple mechanisms of action of azelaic acid: New findings

Journal of the American Academy of Dermatology

2000

Combination azelaic acid therapy for acne vulgaris.

Journal of the American Academy of Dermatology

Horizontal scroll arrowsTwo black arrows facing opposite directions on top of one another to signify the ability to scroll left and right.

SIDE EFFECTS


The most common side effects of azelaic acid are sensations of burning, stinging, or tingling, itching, dryness, peeling or redness of the skin. Skin irritation usually goes away during the course of treatment. Other possible side effects include a severe rash or localized skin swelling. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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