HydroquinoneTargets hyperpigmentation at a cellular level.HydroquinoneTopical MedicationTruecreamretinoidPrescription

A double-blind, comparative, placebo-controlled study of the efficacy and tolerability of 4% hydroquinone as a depigmenting agent in melasma.

Journal of Dermatological Treatment

Hydroquinone is safe and effective for the treatment of melasma.

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The safety of hydroquinone

JEADV

Hydroquinone is safe and effective for the treatment of hyperpigmentary disorders.

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Postinflammatory hyperpigmentation: A comprehensive overview

Journal of the American Academy of Dermatology

In a review of treatment for post-inflammatory hyperpigmentation, hydroquinone is described as the criterion standard skin lightening agent.

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Melasma Update

Indian Dermatology Online Journal

Hydroquinone is the gold standard treatment for melasma.

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A Hydroquinone Solution in the Treatment of Melasma

International Journal of Dermatology

Hydroquinone is effective for the treatment of melasma when used with sunscreen.

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IngredientsHydroquinone

Hq

Topical Medication

C6H6O2

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

TARGETS:

Sun iconBlack outlined circles with black lines radiating around the circle showing a sun.

Inhibits the activity of tyrosinase, the enzyme that produces melanin.

Rosacea IconArray of same sized black circles on a white background.

Promotes the degradation of melanosomes.

BENEFITS:

Melasma

Lentigines (i.e. sun spots, freckles, age spots)

Post-inflammatory hyperpigmentation (e.g. dark spots left by acne)

2009

A double-blind, comparative, placebo-controlled study of the efficacy and tolerability of 4% hydroquinone as a depigmenting agent in melasma.

...

Journal of Dermatological Treatment

2006

The safety of hydroquinone

JEADV

2017

Postinflammatory hyperpigmentation: A comprehensive overview

Journal of the American Academy of Dermatology

2014

Melasma Update

Indian Dermatology Online Journal

1982

A Hydroquinone Solution in the Treatment of Melasma

International Journal of Dermatology

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SIDE EFFECTS


Possible side effects include redness, dryness, peeling, itching, burning, and irritation at the application side. Hydroquinone may produce exogenous ochronosis, a blue-black discoloration of the skin. The risk of ochronosis increases with prolonged use of hydroquinone and continued sun-exposure. To avoid this, periodic breaks from hydroquinone are needed. Always make sure to follow your doctor’s instructions on use. There have been no reported incidences of cancer from topical application of hydroquinone in humans. Though health concerns are related to oral ingestion of hydroquinone, concerns over topical toxicity and carcinogenesis have been raised but not validated when the product is used correctly as directed under the supervision of an appropriately trained, licensed physician.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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