MetronidazoleA topical antibiotic with anti-inflammatory effects.MetronidazoleTopical MedicationTrueShould you become pregnant, please stop this medication and check in with your dermatologist.lotionnitroimidazolesPrescription1%

Current topical and systemic approaches to treatment of rosacea.

Journal of the European Academy of Dermatology and Venereology

A review of topical and systemic approaches to treatment of rosacea, which commonly include the use of topical metronidazole, azelaic acid and doxycycline.

`

Topical metronidazole maintains remissions of rosacea.

JAMA Dermatology

In patients whose rosacea was successfully treated with tetracycline and metronidazole gel, the continued use of topical metronidazole alone caused fewer relapses than the vehicle.

`

A double-blind, multicenter clinical trial comparing efficacy of once-daily metronidazole 1 percent cream to vehicle in patients with rosacea.

Cutis

Metronidazole 1% cream produced a significant reduction in rosacea lesions and facial redness at 10 weeks compared to the vehicle.

`

Topical metronidazole therapy for rosacea.

JAMA Dermatology

In a split-face study, twice daily use of metronidazole 0.75% caused a 65.1% mean reduction in papules and pustules at 9 weeks compared to a reduction of 14.9% in the vehicle-treated side.

`

A double-blind trial of metronidazole versus oxytetracycline therapy for rosacea.

British Journal of Dermatology

Tetracycline 250mg twice daily and metronidazole 200mg twice daily produced an improvement in papulo-pustular rosacea at 12 weeks with no significant difference between them.

`

IngredientsMetronidazole

Metro

Topical Medication

C23H36N2O2

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

TARGETS:

Inflammation IconBlack like with a bump in the middle and a copy of that bump offset above the line.

Inflammation

Rosacea IconArray of same sized black circles on a white background.

Dilated blood vessels

BENEFITS:

Reduces inflamed lesions of rosacea

Decreases facial redness

2009

Current topical and systemic approaches to treatment of rosacea.

Journal of the European Academy of Dermatology and Venereology

1998

Topical metronidazole maintains remissions of rosacea.

JAMA Dermatology

1997

A double-blind, multicenter clinical trial comparing efficacy of once-daily metronidazole 1 percent cream to vehicle in patients with rosacea.

...

Cutis

1987

Topical metronidazole therapy for rosacea.

JAMA Dermatology

1980

A double-blind trial of metronidazole versus oxytetracycline therapy for rosacea.

...

British Journal of Dermatology

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SIDE EFFECTS


Side effects of metronidazole include redness, dryness, stinging, and burning at the application site. Headache may also occur. Allergic reactions to this medication are rare. Symptoms of an allergic reaction include rash, itching/swelling (especially of face/lips/tongue/throat), dizziness, and trouble breathing. Should you become pregnant, please check with your dermatologist to determine whether you should continue this medication.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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