Journal of the European Academy of Dermatology and Venereology

Current topical and systemic approaches to treatment of rosacea.

Journal of the European Academy of Dermatology and Venereology

A review of topical and systemic approaches to treatment of rosacea, which commonly include the use of topical metronidazole, azelaic acid and doxycycline.

2009

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1468-3083.2009.03167.x

JAMA Dermatology

Topical metronidazole maintains remissions of rosacea.

JAMA Dermatology

In patients whose rosacea was successfully treated with tetracycline and metronidazole gel, the continued use of topical metronidazole alone caused fewer relapses than the vehicle.

1998

https://jamanetwork.com/journals/jamadermatology/article-abstract/189144

Cutis

A double-blind, multicenter clinical trial comparing efficacy of once-daily metronidazole 1 percent cream to vehicle in patients with rosacea.

Cutis

Metronidazole 1% cream produced a significant reduction in rosacea lesions and facial redness at 10 weeks compared to the vehicle.

1997

https://europepmc.org/article/med/9466083

JAMA Dermatology

Topical metronidazole therapy for rosacea.

JAMA Dermatology

In a split-face study, twice daily use of metronidazole 0.75% caused a 65.1% mean reduction in papules and pustules at 9 weeks compared to a reduction of 14.9% in the vehicle-treated side.

1987

https://jamanetwork.com/journals/jamadermatology/article-abstract/548260

British Journal of Dermatology

A double-blind trial of metronidazole versus oxytetracycline therapy for rosacea.

British Journal of Dermatology

Tetracycline 250mg twice daily and metronidazole 200mg twice daily produced an improvement in papulo-pustular rosacea at 12 weeks with no significant difference between them.

1980

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.1980.tb06558.x