TretinoinA vitamin A derivative with powerful effects.TretinoinTopical MedicationTrueWomen who are pregnant should not handle this medication.creamretinoidsPrescription.025, .05, .1%

Long-Term Efficacy and Safety of Tretinoin Emollient Cream 0.05% in the Treatment of Photodamaged Facial Skin

American Journal of Clinical Dermatology

Tretinoin 0.05% cream used for >1 year showed significantly greater improvement in fine and coarse wrinkling, mottled hyperpigmentation, lentigines and sallowness compared to placebo cream without histological adverse effects.

`

Comparison of two concentrations of tretinoin solution in the topical treatment of acne vulgaris.

Practitioner

Tretinoin 0.025% and 0.5% solution effectively treated acne after 12 weeks with no improvement seen in the placebo group.

`

Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation: A Double-blind, Vehicle-Controlled Comparison of 0.1% and 0.025% Tretinoin Creams

JAMA Dermatology

Tretinoin 0.025% and 0.1% showed significant improvement in photoaging over the vehicle cream at 48 weeks. There was no statistical difference in efficacy between the two concentrations of tretinoin, but irritant side effects were greater with the higher concentration.

`

Topical tretinoin, vitamin A acid (Airol) in acne vulgaris.

Dermatology

Tretinoin 0.02% and 0.05% was more effective than the vehicle at reducing comedones and papules.

`

Topical tretinoin for photoaged skin

Journal of the American Academy of Dermatology

Tretinoin 0.05% applied to the face and forearms was capable of at least partly reversing the structural damage caused by excessive sunlight exposure based on histologic and physiologic studies.

`

Treatment of photodamaged facial skin with topical tretinoin

Treatment of photodamaged facial skin with topical tretinoin

Tretinoin 0.05% showed significant objective and subjective improvements in fine wrinkling, wrinkling, sallowness, looseness and hyperpigmentation over the vehicle cream in a 6-month randomized, double-blind, vehicle-controlled trial.

`

Tretinoin emollient cream: A new therapy for photodamaged skin

Journal of the American Academy of Dermatology

Tretinoin 0.05% emollient was significantly better than vehicle for treatment of sun-damaged facial skin at 24 wks.

`

A multicentre, single-blind, randomized comparison of a fixed clindamycin phosphate/tretinoin gel formulation (Velac) applied once daily and a clindamycin lotion formulation (Dalacin T) applied twice daily in the topical treatment of acne vulgaris.

British Journal of Dermatology

The combination clindamycin 1%/tretinoin 0.025% once daily was significantly more effective than clindamycin 1% twice daily at reducing inflammatory and non-inflammatory acne lesions.

`

IngredientsTretinoin

Tret

Topical Medication

C20H28O2

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

TARGETS:

Sun iconBlack outlined circles with black lines radiating around the circle showing a sun.

Sun-damaged skin

Fine lines and wrinklesBlack swervy lines with a white background representing wrinkle lines.

Wrinkles and fine lines

Non-Comedogenic IconBlack line with a circle shaped dip in the middle. Three black outlined circles float above.

Clogged pores

Rosacea IconArray of same sized black circles on a white background.

Hyperpigmentation

BENEFITS:

Improves acne of all severities

Effectively controls acne long-term

Reduces fine lines and wrinkles

Improves skin tone and texture

Reduces post-inflammatory hyperpigmentation

2012

Long-Term Efficacy and Safety of Tretinoin Emollient Cream 0.05% in the Treatment of Photodamaged Facial Skin

American Journal of Clinical Dermatology

1976

Comparison of two concentrations of tretinoin solution in the topical treatment of acne vulgaris.

Practitioner

1995

Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation: A Double-blind, Vehicle-Controlled Comparison of 0.1% and 0.025% Tretinoin Creams

JAMA Dermatology

1974

Topical tretinoin, vitamin A acid (Airol) in acne vulgaris.

Dermatology

1986

Topical tretinoin for photoaged skin

Journal of the American Academy of Dermatology

1989

Treatment of photodamaged facial skin with topical tretinoin

Treatment of photodamaged facial skin with topical tretinoin

1992

Tretinoin emollient cream: A new therapy for photodamaged skin

Journal of the American Academy of Dermatology

2000

A multicentre, single-blind, randomized comparison of a fixed clindamycin phosphate/tretinoin gel formulation (Velac) applied once daily and a clindamycin lotion formulation (Dalacin T) applied twice daily in the topical treatment of acne vulgaris.

British Journal of Dermatology

Horizontal scroll arrowsTwo black arrows facing opposite directions on top of one another to signify the ability to scroll left and right.

SIDE EFFECTS


The most common side effects of tretinoin are redness, mild burning and peeling. It can cause sun sensitivity, primarily during the first three months of use. Women who are pregnant should not handle this medication. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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