American Journal of Clinical Dermatology

Long-Term Efficacy and Safety of Tretinoin Emollient Cream 0.05% in the Treatment of Photodamaged Facial Skin

American Journal of Clinical Dermatology

Tretinoin 0.05% cream used for >1 year showed significantly greater improvement in fine and coarse wrinkling, mottled hyperpigmentation, lentigines and sallowness compared to placebo cream without histological adverse effects.

2012

https://link.springer.com/article/10.2165/00128071-200506040-00005

British Journal of Dermatology

A multicentre, single-blind, randomized comparison of a fixed clindamycin phosphate/tretinoin gel formulation (Velac) applied once daily and a clindamycin lotion formulation (Dalacin T) applied twice daily in the topical treatment of acne vulgaris.

British Journal of Dermatology

The combination clindamycin 1%/tretinoin 0.025% once daily was significantly more effective than clindamycin 1% twice daily at reducing inflammatory and non-inflammatory acne lesions.

2000

https://www.ncbi.nlm.nih.gov/pubmed/10971320?dopt=Abstract

JAMA Dermatology

Two Concentrations of Topical Tretinoin (Retinoic Acid) Cause Similar Improvement of Photoaging but Different Degrees of Irritation: A Double-blind, Vehicle-Controlled Comparison of 0.1% and 0.025% Tretinoin Creams

JAMA Dermatology

Tretinoin 0.025% and 0.1% showed significant improvement in photoaging over the vehicle cream at 48 weeks. There was no statistical difference in efficacy between the two concentrations of tretinoin, but irritant side effects were greater with the higher concentration.

1995

https://jamanetwork.com/journals/jamadermatology/article-abstract/557092

Journal of the American Academy of Dermatology

Tretinoin emollient cream: A new therapy for photodamaged skin

Journal of the American Academy of Dermatology

Tretinoin 0.05% emollient was significantly better than vehicle for treatment of sun-damaged facial skin at 24 wks.

1992

https://www.sciencedirect.com/science/article/abs/pii/019096229270030J

Treatment of photodamaged facial skin with topical tretinoin

Treatment of photodamaged facial skin with topical tretinoin

Treatment of photodamaged facial skin with topical tretinoin

Tretinoin 0.05% showed significant objective and subjective improvements in fine wrinkling, wrinkling, sallowness, looseness and hyperpigmentation over the vehicle cream in a 6-month randomized, double-blind, vehicle-controlled trial.

1989

https://www.ncbi.nlm.nih.gov/pubmed/2674225

Journal of the American Academy of Dermatology

Topical tretinoin for photoaged skin

Journal of the American Academy of Dermatology

Tretinoin 0.05% applied to the face and forearms was capable of at least partly reversing the structural damage caused by excessive sunlight exposure based on histologic and physiologic studies.

1986

https://www.sciencedirect.com/science/article/abs/pii/S0190962286702429

Practitioner

Comparison of two concentrations of tretinoin solution in the topical treatment of acne vulgaris.

Practitioner

Tretinoin 0.025% and 0.5% solution effectively treated acne after 12 weeks with no improvement seen in the placebo group.

1976

https://www.ncbi.nlm.nih.gov/pubmed/131310?dopt=Abstract

Dermatology

Topical tretinoin, vitamin A acid (Airol) in acne vulgaris.

Dermatology

Tretinoin 0.02% and 0.05% was more effective than the vehicle at reducing comedones and papules.

1974

https://www.karger.com/Article/Abstract/251602