Common side effects include nausea, diarrhea, loss of appetite, mild itching and rash. Oral thrush or vaginal yeast infections can occur with prolonged use. Long-term use can also cause a decrease in blood cell counts. This drug may rarely cause a severe drug rash called Stevens-Johnson syndrome or toxic epidermal necrolysis. You should stop this medication immediately if you develop sores in the eyes, mouth or genital area or a severe rash. Allergic reaction to this medication is rare. Symptoms of an allergic reaction include rash, itching/swelling (especially of face/tongue/throat), dizziness and trouble breathing. You should not use this medication if you have severe liver or kidney disease or anemia caused by folic acid deficiency. Women who are pregnant should not use this medication.
This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.