NiacinamideA topical B vitamin with proven efficacy.NiacinamideTopical MedicationTruecream, lotionvitamin B3 complexPrescription4%

Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance

Dermatologic Surgery

In a 12-week, split-face, vehicle-controlled study, niacinamide 5% significantly improved fine lines and wrinkles, hyperpigmented spots, red blotchiness, skin sallowness and elasticity over the control.

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Use of nicotinamide in dermatology

Journal of Dermatological Treatment

A review article highlighting the use of nicotinamide (niacinamide) in dermatology and their supporting clinical studies.

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Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris.

International Journal of Dermatology

Nicotinamide 4% was as effective as clindamycin 1% at reducing inflammatory acne after twice daily use for 8 weeks.

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Topical niacinamide reduces yellowing, wrinkling, red blotchiness and hyperpigmented spots in aging facial skin.

International Journal of Cosmetic Science

In a 12-week, split-face, vehicle-controlled study, niacinamide 5% significantly improved fine lines/wrinkles, hyperpigmentation spots, texture, red blotchiness and skin yellowing (sallowness) over the control.

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Niacinamide-containing Facial Moisturizer Improves Skin Barrier and Benefits Subjects with Rosacea.

Cutis

A niacinamide 2% facial moisturizer significantly improved skin barrier function and hydration when used on the forearm twice daily for 4 wks.

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The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.

British Journal of Dermatology

In clinical studies, niacinamide significantly decreased hyperpigmentation over the vehicle after 4 weeks of use.

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The effect of 2% niacinamide on facial sebum production.

Journal of Cosmetic and Laser Therapy

In a double-blind, placebo-controlled study, niacinamide 2% decreased sebum excretion rates in Japanese subjects after 2 and 4 weeks of application compared to the control group. In Caucasian subjects, casual sebum levels were reduced after 6 wks of use compared to the control group.

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An investigation of efficacy of topical niacinamide for the treatment of mild and moderate acne vulgaris.

Journal of the Turkish Academy of Dermatology

Use of a niacinamide 4% gel significantly reduced the number of comedones, papules and pustules after 8 weeks as compared to the onset of treatment.

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IngredientsNiacinamide

Niac

Topical Medication

C6H6N2O

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

TARGETS:

Inflammation IconBlack like with a bump in the middle and a copy of that bump offset above the line.

Inflammation

Rosacea IconArray of same sized black circles on a white background.

Hyperpigmentation

Oil iconTwo tear drop shaped blasck outlines with additional circles and triangles withing representing texture on a white background.

Oil production

Fine lines and wrinklesBlack swervy lines with a white background representing wrinkle lines.

Wrinkles and fine lines

Irritation iconJagged black lines broken into pieces representing the pain of irritation.

Irritated and dry skin

BENEFITS:

Improves mild-to-moderate acne and rosacea

Improves fine lines, wrinkles and hyperpigmentation

Reduces skin dryness and irritation from other ingredients

Decreases facial redness

2006

Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance

Dermatologic Surgery

2017

Use of nicotinamide in dermatology

Journal of Dermatological Treatment

1995

Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris.

...

International Journal of Dermatology

2004

Topical niacinamide reduces yellowing, wrinkling, red blotchiness and hyperpigmented spots in aging facial skin.

...

International Journal of Cosmetic Science

2005

Niacinamide-containing Facial Moisturizer Improves Skin Barrier and Benefits Subjects with Rosacea.

...

Cutis

2002

The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.

...

British Journal of Dermatology

2006

The effect of 2% niacinamide on facial sebum production.

Journal of Cosmetic and Laser Therapy

2008

An investigation of efficacy of topical niacinamide for the treatment of mild and moderate acne vulgaris.

...

Journal of the Turkish Academy of Dermatology

Horizontal scroll arrowsTwo black arrows facing opposite directions on top of one another to signify the ability to scroll left and right.

SIDE EFFECTS


Niacinamide is generally well-tolerated and non-irritating. Possible side effects include mild burning, itching and redness.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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