Tretinoin + Spironolactone + Tranexamic Acid Formula

We want to make sure you fully understand your treatment. 
Below outlines the directions, benefits and risks with 
Tretinoin + Spironolactone + Tranexamic Acid Formula.

This combination medication improves fine lines and scarring, prevents acne, fades dark spots and decreases oil production.

Tretinoin is a retinoid that works by improving cell turnover and promoting the growth of new collagen. Spironolactone is a topical antiandrogen that decreases oil production and reduces acne. Tranexamic acid is an agent that improves hyperpigmentation.

Redness, peeling, and skin sensitivity can occur, so it’s best to ease into treatment. Your skin will adjust to the medication over time.


✔️ Dot one pea-sized drop across your face to evenly distribute, then gently rub in.

✔️ Apply Mon/Wed/Fri for the first 1-2 weeks

✔️ If adjusting well, apply every other night for the next 1-2 weeks

✔️ If adjusting well, apply every night

Note: We do not add any fragrance to mask odors due to the high allergenicity of added fragrance. Your medication will have a slight earthy smell – that is normal.

Apply your cream at night. 🌙 UV breaks down tretinoin, making it less effective.

Use a moisturizer. Apply immediately before or after to prevent irritation. This does not make it less effective.

Always wear sunscreen. ☀️ Tretinoin increases sun sensitivity the first 6 months of use.

Apply over the entire face. 😍 This formula works best when used nightly over the entire face. It is not a spot treatment.

Careful around the eyes. 😚 It’s best avoid the eyelids and the corners of your nose and mouth. It can be cautiously applied under the eyes if desired.

Simplify your routine. Stop using brushes and scrubs, toners, serums, masks, salicylic acid, AHA (e.g. glycolic or lactic acid), and retinol while starting your prescription treatment. When you are tolerating the prescription daily without irritation, you can add other treatments back in if desired (with the exception of retinol and salicylic acid -- these are redundant).

Listen to your skin. If your skin becomes dry or irritated, skip a night or two and apply a moisturizer only. If the irritation persists or becomes severe, stop the medication.


The most common side effects are redness, peeling, dryness, and irritation at the application site.

If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative.