Tretinoin + spironolactone + tranexamic acid formula

Tretinoin + spironolactone + tranexamic acid formula is a topical medication used to improve fine lines and scarring, prevent acne, fade dark spots, and decrease oil production. Tretinoin is a topical retinoid that works by promoting cell turnover and collagen production. Spironolactone is a topical antiandrogen that decreases oil production and reduces acne. Tranexamic acid is an agent that improves hyperpigmentation.


  • Do not use if pregnant.
  • Be sure to apply broad-spectrum SPF 30+ sunscreen every morning. Tretinoin will make your skin more sensitive to the sun, especially during the first 6 months of use.
  • Redness, peeling, and skin sensitivity can occur, so it’s best to ease into treatment. Your skin will adjust to the medicine over time.


  • At bedtime, put a pea-sized amount onto your finger and dot across your clean, dry face.
  • Evenly spread the cream on your face. Avoid your eyelids and the corners of your nose and mouth.
  • Apply a moisturizer either immediately before or after to reduce irritation.
  • If your skin becomes dry or irritated, skip a night or two and apply a moisturizer only. If the irritation persists or becomes severe, stop the medication.


  • The most common side effects of this medication are redness, dryness, stinging, sun sensitivity, and mild-burning at the application site. Skin irritation usually goes away during the course of the treatment.


  • Keep this medication in the container it came in, tightly closed, and out of reach of children.
  • Store at room temperature and away from light, excess heat, and moisture.