Tretinoin + Spironolactone + Clindamycin Formula

We want to make sure you fully understand your treatment. 
Below outlines the directions, benefits and risks with 
Tretinoin +Spironolactone + Clindamycin Formula.

This combination medication is primarily used to treat acne. It also improves fine lines and acne scarring, fades dark spots left by acne, and decreases oil production.

Tretinoin is a retinoid that works by improving cell turnover and promoting the growth of new collagen. Clindamycin is a topical antibiotic that kills acne-causing bacteria and decreases skin inflammation. Spironolactone is a topical antiandrogen that decreases oil production and reduces acne.

Redness, peeling, and skin sensitivity can occur, so it’s best to ease into treatment. Your skin will adjust to the medication over time.


✔️ Dot one pea-sized drop across your face to evenly distribute, then gently rub in.

✔️ Apply Mon/Wed/Fri for 1-2 weeks

✔️ If adjusting well, apply every other night for 1-2 weeks

✔️ If adjusting well, apply every night

Note: We do not add any fragrance to mask odors due to the high allergenicity of added fragrance. Your medication will have a slight earthy smell – that is normal.

Apply your cream at night. 🌙 UV breaks down tretinoin, making it less effective.

Use a moisturizer. Apply immediately before or after to prevent irritation. This does not make it less effective.

Always wear sunscreen. ☀️ Tretinoin increases sun sensitivity the first 6 months of use.

Apply over the entire face. 😍 This formula works best to prevent acne. It is not a spot treatment.

Careful around the eyes. 😚 It’s best avoid the eyelids and the corners of your nose and mouth. It can be cautiously applied under the eyes if desired.

Simplify your routine. Stop using brushes and scrubs, toners, serums, masks, salicylic acid, AHA (e.g. glycolic or lactic acid), and retinol while starting your prescription treatment. When you are tolerating the prescription daily without irritation, you can add other treatments back in if desired (with the exception of retinol and salicylic acid -- these are redundant).

Listen to your skin. If your skin becomes dry or irritated, skip a night or two and apply a moisturizer only. If the irritation persists or becomes severe, stop the medication.

Caution: The most common side effects are redness, peeling, dryness, and irritation at the application site.

If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative.