Tretinoin + niacinamide formula

Tretinoin + niacinamide formula is a topical medication used to treat and prevent acne, wrinkles, and post-inflammatory hyperpigmentation. Tretinoin works by improving cell turnover and promoting the growth of new collagen. Niacinamide is a vitamin b derivative that helps to balance oil production and improve tolerability with prescription treatments.


  • Do not use if pregnant.
  • Avoid direct sun exposure, tanning beds, and sun lamps.
  • Be sure to apply broad-spectrum SPF 30+ sunscreen every morning. Tretinoin will make your skin more sensitive to the sun, especially during the first 6 months of use.
  • Redness, peeling, and skin sensitivity can occur, so it’s best to ease into treatment. Your skin will adjust to the medicine over time.


  • Dot a pea-sized amount of your topical treatment on your forehead, cheeks, and chin.
  • Evenly spread the treatment across your face. Avoid your eyelids and the corners of your nose and mouth.
  • Apply a moisturizer either immediately before or after you apply your topical treatment.
  • If your skin becomes irritated, reduce frequency of use. If the irritation persists, stop the medication and contact your dermatology team.


  • The most common side effects of tretinoin are redness, mild burning, dryness, stinging, peeling, and sun sensitivity. Skin irritation usually goes away during the course of the treatment.


  • Keep this medication in the container it came in, tightly closed, and out of reach of children.
  • Store it at room temperature and away from light, excess heat, and moisture.