Tretinoin + Clindamycin Formula

We want to make sure you fully understand your treatment. 
Below outlines the directions, benefits and risks with Tretinoin + Clindamycin Formula.

This combination medication is used to treat acne. It is also used to treat wrinkles and acne scarring, including postinflammatory hyperpigmentation.

Tretinoin works by improving cell turnover and promoting the growth of new collagen. Clindamycin primarily works through its anti-inflammatory effects.

Redness, peeling, and skin sensitivity can occur, so it’s best to ease into treatment. Your skin will adjust to the medicine over time.


✔️ Apply Mon/Wed/Fri for 1-2 weeks

✔️ If adjusting well, apply every other night for 1-2 weeks

✔️ If adjusting well, apply every night

Apply your cream at night. 🌙 UV breaks down tretinoin, making it less effective.

Use a moisturizer. Apply immediately before or after to prevent irritation. This does not make it less effective.

Always wear sunscreen. ☀️ Tretinoin increases sun sensitivity the first 6 months of use.

Apply over the entire face. Tretinoin+Clindamycin works best to prevent breakouts, not as a spot treatment. Dot one pea-sized drop across your face to evenly distribute, then gently rub in.

Go easy on the eyes. You may cautiously apply under the eyes but avoid the corners of your nose and mouth.

Simplify your routine. Stop using brushes and scrubs, toners, serums, masks, salicylic acid, AHA (e.g. glycolic or lactic acid), and retinol while starting your prescription treatment. When you are tolerating the prescription daily without irritation, you can add other treatments back in (with the exception of retinol and salicylic acid -- these are redundant).

Listen to your skin. If your skin becomes mildly irritated, reduce frequency of use. If the irritation persists or is severe, stop the medication.


The most common side effects are redness, peeling, dryness, and irritation at the application site.

If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative.