medication information

Tretinoin + Clindamycin Formula

We want to make sure you fully understand your treatment. 
Below outlines the benefits, expectations, and risks with 
Tretinoin + Clindamycin Formula.

Both tretinoin and clindamycin are used to treat acne. Tretinoin helps skin cells shed properly thereby preventing clogged pores. It promotes collagen production and may help with mild scarring over time. Clindamycin is a topical antibiotic that kills acne-causing bacteria and decreases inflammation in the skin.

Redness, peeling and skin sensitivity can occur but following the instructions below will help minimize these side effects. Your skin will adjust to the medicine over time.


Tretinoin + Clindamycin Formula should only be applied to your skin once a day, before bedtime.

  • After gently washing your face, apply a small pea-sized amount to your entire face. Avoid applying the medication near your eyelids or around the corners of your mouth and nose.
  • Always apply a facial moisturizer either immediately before, or immediately after.
  • This formula works best to prevent breakouts, not as a spot treatment.

Note: It is best to start using this medication every other night for the first 2-4 weeks, then increase to nightly use as tolerated.

Tips to avoid side effects:

  • Make sure you apply a thin layer on the skin. Using more does not always mean it will work better.
  • You can pre-mix the Tretinoin + Clindamycin Formula in your palm with a liberal amount of facial moisturizer before applying.
  • If your skin becomes irritated, skip a night or two but still apply a facial moisturizer. You can resume the medication once the irritation has subsided.
  • This medication will make your skin more sensitive to the sun during the first 6 months of use. Make sure you wear sunscreen with SPF 30 or higher every morning, and wide-brimmed hats whenever outdoors in the sun.

Risks to be aware of:

The most common side effects of this medication are redness, peeling, dryness, and irritation at the application side. Tretinoin increases sensitivity to the sun, especially during the first 6 months of use. Rare side effects include abdominal pain and diarrhea that is watery or bloody.

If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative.

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