We want to make sure you fully understand your treatment. 
Below outlines the directions, benefits and risks with sulfamethoxazole-trimethoprim.

Sulfamethoxazole-trimethoprim (aka Bactrim) is an oral antibiotic used to treat acne and rosacea. It works primarily by reducing inflammation.

Oral antibiotics are used as bridge therapy while topical medicines take effect. They should always be taken with topical treatment. Patients typically take this medication for 3-6 months, after which topical treatments are continued to keep skin clear.


Take as instructed. Be consistent for best results and to minimize side effects.

May take with food. This can help prevent stomach upset.

Drink plenty of water. 🚰

Take a probiotic. This can help prevent yeast infections and maintain healthy gut bacteria.

Do NOT take this medication if:

  • You are allergic to sulfa drugs (sulfonamide) or trimethoprim.
  • You are pregnant or nursing.
  • You have liver or kidney problems.
  • You are taking methotrexate, indomethacin or a potassium-sparing diuretic such as an ACE inhibitor.


The most common side effects are nausea, vomiting, diarrhea, loss of appetite, and allergic skin reactions such as rash and hives. Stop this medication if you develop hives, worsening diarrhea, or any unusual side effects.

Although rare, this medication can cause a very severe drug rash called Stevens-Johnson syndrome. You should stop this medication and message your doctor immediately if you have a skin rash, especially one involving your mouth or genital area. For severe symptoms, go to the nearest emergency room.

If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative.

Do not take if breastfeeding.