Hydroquinone + Tretinoin + Fluocinolone Formula

We want to make sure you fully understand your treatment. 
Below outlines the directions, benefits and risks with 
Hydroquinone + Tretinoin + Fluocinolone Formula

This triple combination lightening cream helps improve the appearance of melasma and other hyperpigmentation. It should always be used with sun protection measures, like daily sunscreen use and wide-brimmed hats.

This cream is not intended for long-term treatment. Once improvement is achieved, therapy should be switched to an alternative treatment to maintain improvement.


Apply your cream at night. 🌙 UV breaks down tretinoin, making it less effective.

Apply to dark patches only. This medication should be used as a spot treatment.

Use a moisturizer. Apply immediately before or after to prevent irritation. This does not make it less effective.

Always wear sunscreen. ☀️ Even minimal sunlight promotes skin darkening.

Avoid the eyes. Avoid the corners of your nose and mouth too.

Simplify your routine. Stop using brushes and scrubs, toners, serums, masks, salicylic acid, AHA (e.g. glycolic or lactic acid), and retinol while starting your prescription treatment. When you are tolerating the prescription daily without irritation, you can add other treatments back in.

Listen to your skin. If your skin becomes mildly irritated, reduce frequency of use. If the irritation persists or is severe, stop the medication.


Possible side effects include redness, dryness, peeling, itching, burning, and irritation at the application side.

Hydroquinone may produce exogenous ochronosis, a blue-black discoloration of the skin. The risk of ochronosis increases with prolonged use of hydroquinone and continued sun-exposure. To avoid this, periodic breaks from hydroquinone are needed. Always make sure to follow your doctor’s instructions on use.

There have been no reports of cancer caused by topical application of hydroquinone in humans.

If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative. This medication should not be used if you are breastfeeding.


Store in a cool, dry place. Slight darkening of products containing hydroquinone is normal. This does not affect the potency of the product and can be safely used until the expiration date.