Aczone Gel (dapsone)

We want to make sure you fully understand your treatment. 
Below outlines the directions, benefits, expectations, and risks with Dapsone.

Aczone gel (dapsone) is a prescription medication that treats acne through its anti-inflammatory and antimicrobial effects.


Aczone should be applied to your skin once or twice a day, as recommended by your doctor. Dryness and itching can be experienced with treatment. Please follow the instructions below to minimize these side effects.

  • Apply a thin layer to the entire acne-prone area. Aczone works best to prevent pimples, not as a spot treatment.
  • Apply a moisturizer afterwards to minimize skin irritation.

A few things to keep in mind:

  • This medication typically takes 12 weeks before you see a major improvement. Be patient and continue to apply it throughout its full course. If your acne is not improving after 12 weeks, contact your dermatologist in your dashboard.
  • Avoid using benzoyl peroxide immediately before or after applying Aczone. Using benzoyl peroxide with Aczone may case your skin or facial hair to temporarily turn yellow at the site of application.
  • Skip a night or two if your skin becomes irritated, but still apply a facial moisturizer. You can resume the medication once the irritation has subsided.

Safety warnings:

  • Tell your doctor if you have glucose-6-phosphate-dehydrogenase deficiency (G6PD) or higher than normal levels of methemoglobin in your blood (methemoglobenemia). Although Aczone is a very safe medication in general, it can rarely cause severe side effects in patients with these conditions.
  • If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative.
  • Do not use Aczone if you are breastfeeding.