We want to make sure you fully understand your treatment. 
Below outlines the directions, benefits, expectations, and risks with Epiduo.

Epiduo is an acne medication that combines a topical retinoid (adapalene) with benzoyl peroxide. Benzoyl peroxide kills acne-causing bacteria and reduces inflammation, while adapalene works in a variety of ways including helping skin cells shed properly thereby preventing clogged pores.

Redness, peeling and skin sensitivity can be experienced with treatment, but following the instructions below will help minimize these side effects. Irritation is not necessary for the medicine to be effective. Your skin will adjust to the medicine over time.


Epiduo should only be applied to your skin once a day, before bedtime.

  • After gently washing your face, apply a small pea-sized amount to your entire face. Avoid applying the medication near your eyelids or around the corners of your mouth and nose.
  • Always apply a facial moisturizer after.

Note: If this is your first time using Epiduo, it is best to start using it every other night for the first couple of weeks, and then increase to nightly use as tolerated.

A few things to keep in mind:

  • You do not need to wait 20 minutes for your skin to dry before applying the medicine.
  • This medication will make your skin more sensitive to the sun. Make sure you wear a sunscreen with SPF 30 or higher every morning, and wide-brimmed hats whenever outdoors in the sun.
  • The benzoyl peroxide in this medication can bleach clothes and towels – Be careful!

Some helpful tips if you experience irritation:

  • Make sure you are applying a small, pea-sized amount or less for your entire face. Using more does not mean it will work better.
  • You may pre-mix the Epiduo in your palm with a liberal amount of facial moisturizer before applying. Alternatively, you can apply a facial moisturizer first, and then apply the Epiduo afterward.
  • Skip a night or two if your skin becomes irritated, but still apply a facial moisturizer. You can resume the medication once the irritation has subsided.

Consistent usage is key!

If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative.