Clindamycin and Benzoyl Peroxide Gel

We want to make sure you fully understand your treatment. 
Below outlines the directions, benefits, expectations, and risks with clindamycin and benzoyl peroxide gel .

This treatment is a gel that includes two active ingredients. Clindamycin is an antibiotic, while benzoyl peroxide is an antimicrobial. Both kill acne-causing bacteria and decrease inflammation in the skin, thereby treating acne. In addition, benzoyl peroxide prevents antibiotic resistance, which allows the medication to remain effective over time.


  • Apply a small amount to the entire acne-prone area as directed. This medicine works best to prevent pimples, not as a spot treatment.
  • Avoid getting the medication very close to your eyes or near the corners of your mouth and nose. Do not wash off the gel.

Tips to avoid irritation:

  • If your skin dries easily, apply a facial moisturizer over your entire face immediately after applying the medication.

A few things to keep in mind:

  • Even if your acne starts to get better, keep applying the medication to keep your acne under control.
  • Benzoyl peroxide can bleach clothing and towels -- be careful!
  • Benzoyl peroxide can break down generic tretinoin, making it ineffective. This medication should not be applied at the same time as generic tretinoin.
  • Consistent usage is key!

Alergy alert:

This medication very rarely can cause severe adverse reactions in some patients. Stop using it and seek emergency help if you experience severe swelling, shortness of breath, or severe diarrhea.

If you become pregnant while taking this medication, discontinue use immediately and message your doctor for an alternative.