Tranexamic AcidA game changer for melasma.Tranexamic AcidTopical MedicationTruecreamretinoidsPrescription0.018, 0.025, 0.05, 0.1%

Randomized, placebo-controlled, double-blind study of oral tranexamic acid in the treatment of moderate-to-severe melasma

JAAD

In a randomized, double-blind, placebo-controlled trial, oral TXA appeared to be an effective treatment for moderate-to-severe melasma with minimal side effects.

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Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

JAAD

Oral TXA may be effective for otherwise treatment-resistant melasma.

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Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

JEADV

TXA decreased epidermal pigmentation associated with melasma and also reversed melasma‐related dermal changes, such as vessel number and increased numbers of mast cells.

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Topical 5% tranexamic acid for acne-related postinflammatory erythema.

JAAD

Topical TXA reduced postinflammatory erythema after 8 weeks.

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Clinical evaluation of a facial serum containing 3% tranexamic acid on women with mild to moderate skin pigmentation conditions

Journal of the American Academy of Dermatology

A facial serum containing TXA reduced hyperpigmentation.

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IngredientsTranexamic Acid

TXA

Topical Medication

C20H28O2

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

TARGETS:

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Inhibits melanin synthesis.

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Reduces redness and decreases abnormal blood vessels.

BENEFITS:

Improves moderate-to-severe melasma.

Improves melasma that does not respond to other treatments.

2018

Randomized, placebo-controlled, double-blind study of oral tranexamic acid in the treatment of moderate-to-severe melasma

...

JAAD

2016

Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

...

JAAD

2012

Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis

...

JEADV

2019

Topical 5% tranexamic acid for acne-related postinflammatory erythema.

JAAD

2019

Clinical evaluation of a facial serum containing 3% tranexamic acid on women with mild to moderate skin pigmentation conditions

...

Journal of the American Academy of Dermatology

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SIDE EFFECTS


The most common side effects include stomach upset, nausea, changes in menstrual periods (lighter or absent periods), headache, muscle aches, joint pain, muscle cramps, migraine, and fatigue. This medication should not be taken if you are pregnant or breastfeeding. This medication may increase the risk of blood clots. Stop this medication and seek medical attention if you develop swelling in one or both legs, difficulty breathing, eye symptoms or changes in vision. If you develop vision changes, you should see an ophthalmologist immediately for evaluation, including a dilated retinal examination. Do not take this medication if you suspect you have COVID-19. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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