FluocinoloneA mild corticosteroid that reduces inflammation.FluocinoloneTopical MedicationTruelotioncorticosteroidsPrescription

Rationale for the use of topical corticosteroids in melasma.

Journal of Drugs in Dermatology

Fluocinolone in combination with hydroquinone and tretinoin leads to early treatment response in melasma.

`

Efficacy and Safety of a New Triple-Combination Agent for the Treatment of Facial Melasma

Therapeutics For The Clinician

The use of a triple-combination cream containing tretinoin, hydroquinone and fluocinolone was more effective than other skin-lightening combinations.

`

A Histological Examination for Skin Atrophy After 6 Months of Treatment With Fluocinolone Acetonide 0.01%, Hydroquinone 4%, and Tretinoin 0.05% Cream

The American Journal of Dermatopathology

There was no histopathological signs of skin atrophy noted after use of a triple-combination cream containing hydroquinone, tretinoin and fluocinolone for 24 weeks.

`

A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0·01%, hydroquinone 4%, tretinoin 0·05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma

British Journal of Dermatology

A triple-combination cream containing hydroquinone, tretinoin and fluocinolone was more effective than hydroquinone alone for the treatment of melasma.

`

Hydroquinone 4%, Tretinoin 0.05%, Fluocinolone Acetonide 0.01%: A Safe and Efficacious 12-Month Treatment for Melasma

Therapeutics For The Clinician

The combination of hydroquinone, tretinoin and fluocinolone is a safe and effective treatment for melasma.

`

IngredientsFluocinolone

Flcn

Topical Medication

C21H26F2O6

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

TARGETS:

Inflammation IconBlack like with a bump in the middle and a copy of that bump offset above the line.

Skin inflammation

BENEFITS:

Reduces the irritating effects of hydroquinone and tretinoin

2004

Rationale for the use of topical corticosteroids in melasma.

Journal of Drugs in Dermatology

2003

Efficacy and Safety of a New Triple-Combination Agent for the Treatment of Facial Melasma

...

Therapeutics For The Clinician

2009

A Histological Examination for Skin Atrophy After 6 Months of Treatment With Fluocinolone Acetonide 0.01%, Hydroquinone 4%, and Tretinoin 0.05% Cream

...

The American Journal of Dermatopathology

2008

A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0·01%, hydroquinone 4%, tretinoin 0·05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma

...

British Journal of Dermatology

2005

Hydroquinone 4%, Tretinoin 0.05%, Fluocinolone Acetonide 0.01%: A Safe and Efficacious 12-Month Treatment for Melasma

...

Therapeutics For The Clinician

Horizontal scroll arrowsTwo black arrows facing opposite directions on top of one another to signify the ability to scroll left and right.

SIDE EFFECTS


The following skin reactions have been observed with topical steroids: folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, and miliaria. Risks are higher with prolonged use and with higher potency corticosteroids. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of side effects and others may occur. Contact your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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