Easiest way to get prescription acne treatment online.

The best way to tackle acne is from the outside-in and the inside-out. That's why we offer both gold-standard topical and oral treatments to get you to clearer, healthier skin in less time.

Circled CheckmarkGray circle outline with white background containing gray checkmark in the center.
Custom treatments to address your skin concerns
Circled CheckmarkGray circle outline with white background containing gray checkmark in the center.
Prescribed by board-certified dermatologists
Circled CheckmarkGray circle outline with white background containing gray checkmark in the center.
Free deliveries, so you never miss a dose

A comprehensive visit is just $20, which get credited towards any prescription purchase.

ForbesCreated with Sketch.
logo color@2x
womens-wear-daily-wwd-vector-logoCreated with Sketch.
Pfad_1Created with Sketch.
Refinery29_logo@2x

Our patients

Real patients. Real results.

5.00 0 reviews

After attempting to manage my adult acne for over 6 months on my own, I decided to take a chance on Apostrophe. I can now say 8 months into my treatment plan that I have never had more flawless skin. Now it's 100% me and for that I am forever thankful!

Betzabeth

Apostrophe LineLong straight black line with an apostrope at the right most point.

concern

acne

melasma

rx treatment

Tretinoin Formula

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

Spironolactone

Oral medication icon clear backgroundBlack, pill shaped outline with white background.
Maggie Kober, MD

I’ve been struggling with my acne for about five years. Being quarantined brought along stress that took a toll on my skin. Not having access to an in-person dermatologist, I found Apostrophe! I am reaching a content state with my skin again and that has played a huge role in my skin journey!

Andy

Apostrophe LineLong straight black line with an apostrope at the right most point.

concern

breakouts

rx treatment

Tretinoin Formula

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

Doxycycline

Oral medication icon clear backgroundBlack, pill shaped outline with white background.
Maggie Kober, MD

When I turned 28, I developed acne for the first time in my life. I came across a testimonial about Apostrophe. I went to their site and within days I had a treatment plan and prescription sent to me. My face cleared up almost immediately, and 4 months later it’s completely clear and glowing!

Lauren

Apostrophe LineLong straight black line with an apostrope at the right most point.

concern

acne

rx treatment

Metronidazole Formula

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.
Lauren Kyle, MD

After attempting to manage my adult acne on my own, I decided to try Apostrophe. 8 months into my treatment plan, I never had more flawless skin in my life. No more painful acne or horrific flare ups. I finally feel beautiful make up free!

Celeste

Apostrophe LineLong straight black line with an apostrope at the right most point.

concern

acne

rx treatment

Clindamycin Formula

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

Spironolactone

Oral medication icon clear backgroundBlack, pill shaped outline with white background.
Maggie Kober, MD

I was able to see a doctor immediately and was given prescriptions right away, a few days later they arrived in the mail and a few months later my skin has truly never been better. I’m so thankful and grateful to them!

Charlotte

Apostrophe LineLong straight black line with an apostrope at the right most point.

concern

acne

rx treatment

Tretinoin Formula

Topical medication icon clear backgroundBlack tear drop shaped outline with a white backdrop.

Spironolactone

Oral medication icon clear backgroundBlack, pill shaped outline with white background.
Tina Chen, MD
 
Group 12

Group 12

How it works

Confidence Delivered

1

Quick online consultation

Tell us about your skin goals and snap some selfies. Your derm will assess your profile

2

Custom formula is compounded

Your derm will design a custom treatment and we’ll formulate it specifically for you in our lab

3

Your treatment begins

Your treatment is delivered to your door and you’ll have ongoing access to your derm

BOARD-CERTIFIED DOCTORS

Access expert medical care online, always.

At Apostrophe, we know that the best way to treat acne is with science. So we’ve built an ecosystem that supports you on your acne journey from start to finish.

Bullet PointDark black circle
Board-certified dermatologists
Online derm visit, acne assessment, ongoing follow-up appointments and access via messaging
Bullet PointDark black circle
Expert pharmacists and technicians
Every formula created is meticulously measured, mixed, and tested for potency and stability
Bullet PointDark black circle
Science-forward blog backed by a Chemist
Our digital magazine, Slather fights skincare fiction with a potent dose of experts, evidence, and education
Apostrophe SealThe seal of Apostrophe. Round black and white outlined circle with the text "Developed by Apostrophe. Proprietary blend" around the borders of the circle. Contains the Apostrophe A logo in the middle surrounded by two apostrophes along the circles border.

Your treatment plan

Everything you need, nothing you don’t.

Apostrophe’s proprietary topical formula is matched with proven oral treatments to get you on track to clearer, healthier skin.

Bullet PointDark black circle
Topical medications
Targets the root cause of acne– clogged pores
Bullet PointDark black circle
Oral medications
Quickly reduce inflammation to kickstart rapid improvement

“Acne medications work best in combination since we’re able to target acne from different angles”

Aimee paik, md

Topical medication

Customized power-packed topical cream.

Bullet PointDark black circle
Personalized to you
Our derms prescribe a custom formula with clinically-proven actives tailored to your unique skin concerns
Bullet PointDark black circle
Non-comedogenic
Our formulas are free of ingredients that have pore clogging potential and are designed for acne-prone skin
Bullet PointDark black circle
Non-irritating
We use soothing ingredients like 4% niacinamide, aloe and vitamin E to calm irritation that can come from prescription treatment

$25

per month

Moisturizing

Arrow 1Upoward right pointing black outline arrow.

Oral medication

Your clear skin secret weapon.

Kickstart your acne treatment with oral medications. Think of them as your topical treatment’s partner in crime.

Bullet PointDark black circle
Antibiotics
Typically short course treatments that help get your acne under control quicker. Your doctor will only prescribe these if they feel you’ll get better results
Bullet PointDark black circle
Hormonal treatment
For women who experience jawline breakouts caused by hormonal imbalances. Your doctor will only prescribe this if they feel you’re a good candidate

Starting at

$16

per month

Active Ingredients

Prescription ingredients, tailored to your skin goals

You don’t need to spend a lot of money on products with excessive ingredients to have healthy skin. We believe credible ingredients and expert advice, personalized to you, are what matters most.


Tretinoin

Vitamin A derivative used to effectively control acne and improve skin tone and texture


Metronidazole

A potent topical anitbiotic with anti-inflammatory effects


Clindamycin

A powerful topical anitbiotic that helps to mitigate inflammation


Azelaic Acid

Vitamin A derivative used to effectively control acne and improves skin tone and texture


Tazarotene

The most potent retinoid available to effectively combat acne


Hydroquinone

A topical that targets hyperpigmentation at a cellular level for the highest efficacy

Group 12

Group 12

Your skin, your solution
Black underlineBlack squiggly underline for text.

Tell us about yourself and your skin. Persistent chin acne? Scarring on your cheeks?

We want to know the details so we can help.

FAQs


What acne medications can I get from Apostrophe?

Caret iconBlack upwards facing triangle to reference things above or scroll to the top of page.

Apostrophe offers a variety of topical and oral medications for the treatment of acne. Once your dermatologist reviews your information, they will prescribe medications they believe will be most effective for your skin. The most commonly prescribed medications are the following:


What are the side effects of acne medications?

Caret iconBlack upwards facing triangle to reference things above or scroll to the top of page.

If your medication’s side effects are too irritating or intolerable for continued use, please discontinue use and contact your dermatologist through your Patient Account. Your dermatologist will work with you to create a new treatment plan. If you are experiencing a severe reaction to your medication, dial 911 and seek medical attention immediately.

Here is a list of the most common side effects associated with the common medications that are prescribed at Apostrophe.

Tretinoin Formula (tretinoin 0.025% to 0.1% and niacinamide)

The most common side effects of tretinoin are redness and peeling. This medication may make you more sensitive to the sun. Women who are pregnant or who may become pregnant should not handle this medication. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Metronidazole Formula (metronidazole 1% and 4% niacinamide)

Side effects of metronidazole include: redness, dryness, stinging, and burning at the application site. Headache and nausea may also occur. Rarely, metronidazole can cause an allergic reaction. Symptoms of an allergic reaction include rash, itching/swelling (especially of face/lips/tongue/throat), dizziness, and trouble breathing.

Benzoyl Peroxide Formula (benzoyl peroxide 3.1%)

Common side effects of benzoyl peroxide include redness, irritation and peeling. Benzoyl peroxide can also cause bleaching of clothing/linens but not the skin. Rarely, benzoyl peroxide can cause an allergic reaction. Symptoms of an allergic reaction may include: rash, itching/swelling (especially of face/lips/tongue/throat), feeling light-headed, and difficulty breathing. Women who are pregnant should not use this medication.

Tretinoin + Clindamycin Formula (tretinoin 0.025% to 0.1% and clindamycin 1% and niacinamide 4%)

The most common side effects of this medication are redness, peeling, dryness, and irritation at application site. This medication may make you more sensitive to the sun. Rare side effects may include abdominal pain and diarrhea that is watery or bloody. Rarely, this medication can cause an allergic reaction. Symptoms of an allergic reaction may include: rash, itching/swelling (especially of face/lips/tongue/throat), feeling light-headed, and difficulty breathing. Women who are pregnant should not use this medication.

Clindamycin + Benzoyl Peroxide Formula (clindamycin 1% and benzoyl peroxide  3% and niacinamide 4%)

Common side effects of clindamycin and benzoyl peroxide are dryness, redness, stinging, and peeling. Rare side effects may include abdominal pain and diarrhea that is watery or bloody. Rarely, this medication can cause an allergic reaction. Symptoms of an allergic reaction may include: rash, itching/swelling (especially of face/lips/tongue/throat), feeling light-headed, and difficulty breathing. 

Clindamycin Formula (clindamycin 1% and niacinamide 4%)

Side effects of clindamycin include redness, dryness, stinging, irritation or oiliness, and peeling. Rare side effects include abdominal pain and diarrhea that is watery or bloody.Symptoms of an allergic reaction may include: rash, itching/swelling (especially of face/lips/tongue/throat), feeling light-headed, and difficulty breathing. 

Doxycycline (doxycycline 20mg to 100mg oral pills)

The most common side effects of doxycycline are nausea, vomiting, diarrhea, and loss of appetite. This medication will make you more sensitive to the sun. Doxycycline can become lodged in the esophagus if not taken with sufficient water where it can cause esophagitis and ulceration.  Allergic reaction to this medication is rare. Symptoms of an allergic reaction include: rash, itching/swelling (especially of face/tongue/throat), dizziness and trouble breathing. Women who are pregnant should not use this medication.

Minocycline (minocycline 50mg to 100mg oral capsules)

Common side effects of minocycline include: upset stomach, nausea, vomiting, diarrhea, dizziness, lightheadedness, and drowsiness.  This medication may make you more sensitive to the sun. Allergic reaction to this medication is rare. Symptoms of an allergic reaction include: rash, itching/swelling (especially of face/tongue/throat), dizziness and trouble breathing. Women who are pregnant should not use this medication.

Sulfamethoxazole-Trimethoprim (sulfamethoxazole-trimethoprim 800 mg-160 mg oral tablets - generic form of bactrim)

Common side effects include: nausea, vomiting, loss of appetite, dizziness, tiredness, insomnia, painful/swollen tongue. Serious side effects may include: severe skin rash, bruising, itching, sore throat, jaundice. Women who are pregnant should not use this medication. If you have a sulfa allergy you should not use this medication.

Spironolactone (spironolactone 50mg to 100mg oral tablets)

Common side effects of spironolactone include: headache, dizziness, rash, nausea, vomiting, stomach pain, menstrual irregularities, breast tenderness. Serious side effects may include: irregular heart rate, little/no urination, muscle pain/weakness. Allergic reaction to this medication is rare. Symptoms of an allergic reaction include: rash, itching/swelling (especially of face/tongue/throat), dizziness and trouble breathing. Spironolactone can cause severe birth defects. This medication should not be used by women who are pregnant, may become pregnant, or are at a high risk of pregnancy.

Ampicillin (ampicillin 500mg oral capsules)

Common side effects include: diarrhea, stomach upset, nausea, and vomiting. Symptoms of an allergic reaction include: hives, rash, itching, fever, shortness of breath, and anaphylaxis. Women who are pregnant should not use this medication.

Cephalexin (cephalexin 250mg to 500mg oral capsules)

Side effects include: diarrhea, stomach upset, nausea, and vomiting. Allergic reaction to this medication is rare. Symptoms of an allergic reaction include: rash, itching/swelling (especially of face/tongue/throat), dizziness and trouble breathing. Women who are pregnant should not use this medication.


Am I guaranteed a prescription medication with my visit?

Caret iconBlack upwards facing triangle to reference things above or scroll to the top of page.

Although we cannot guarantee that you will receive a prescription, most of our patients do. If you are interested in a specific medication, let your doctor know and they will take this into account when creating your treatment plan and decide whether or not you are a good candidate for that medication. If your doctor decides they are unable to treat you, we will provide a full refund.


What ingredients are in Topical Formulas?

Caret iconBlack upwards facing triangle to reference things above or scroll to the top of page.

All of our topical prescriptions contain the same inactive ingredients: 

The full list of ingredients contains:  

Active: Prescription Medication as prescribed by your physician
Inactive: Aloe Barbadensis Leaf Juice, C 13-14 Isoparaffin, Caprylic/Capric Triglyceride, Deionized Water, Laureth-7, Phenoxyethanol, Polyacrylamide, Tocopheryl Acetate, Triethylene Glycol

Prescription inactive ingredients are not required by the FDA to be listed in order of concentration. 

The topical formulas are vegan. 


My acne has gotten better but now I am left with dark marks and acne scars. How can I get rid of these?

Caret iconBlack upwards facing triangle to reference things above or scroll to the top of page.

Our goal is to treat and prevent active acne. But once acne goes away, there are often red or brown spots at prior sites and the skin might not actually look better, which can be very disheartening. The good news is that skin discoloration is not permanent. It will fade on its own. Red spots can take about 6 months to fade after acne has resolved, while hyperpigmented spots can take up to a year. Once this discoloration does fade (and it will!), your skin will really look clear. 

Daily sun protection is very important to help this discoloration fade more quickly. You should use a sunscreen with SPF 30 or higher every morning and wide-brimmed hats whenever outdoors. Regular use of tretinoin can help hyperpigmentation fade more quickly by increasing cell turnover. Other agents such as azelaic acid and hydroquinone can also be helpful. If you would think you would benefit from one of these other prescription medications, please submit a follow-up visit to your dermatologist. 

Scars are permanent depressions (or pits) in the skin. Tretinoin is the best topical medication for treating mild acne scars. Tretinoin builds up collagen after 6 months with continued improvement with further use. It can help improve the appearance of scars but is unlikely to get rid of deep acne scarring. Procedures such as lasers or acid peels are the most effective for this type of scarring, which would require an in person dermatologist consultation.


How are Apostrophe medications different from generics?

Caret iconBlack upwards facing triangle to reference things above or scroll to the top of page.

We believe Apostrophe medications are better than their generic counterparts for a few reasons. 

Niacinamide is added to many of our formulations because of its versatility and proven efficacy against common skin concerns such as inflammation, skin discoloration, and sun-damage. 

In contrast to generic medicines, special attention was also paid to the vehicle in which the medications are delivered, since this plays a significant role in a medicine’s overall efficacy. Apostrophe medications are delivered in moisturizing creams or lotions that are cosmetically elegant and serve to minimize skin irritation. Importantly, certain inactive ingredients were deliberately excluded. Apostrophe medications avoid fragrances, alcohol, dyes, unnecessary plant extracts, and certain allergenic preservatives. When generic medicines are prescribed, the exact inactive ingredients are unknown by the prescriber and can be variable. 

At Apostrophe, all active and inactive ingredients have been carefully considered, which is why we believe they are better than their generic counterparts.


How long does it take to see results?

Caret iconBlack upwards facing triangle to reference things above or scroll to the top of page.

Acne treatment truly is a skin journey. Acne treatments take time to work. While minimal improvement may be noted in the first 2 months of treatment, results really start to kick in during the third month of treatment and beyond. While those with milder acne may experience rapid improvement, moderate-to-severe acne typically takes about 6-9 months (or longer) to clear. There is a delicate balance between using strong medications that are more effective and avoiding side effects. The skin often needs time to adjust to treatment in a stepwise fashion.  

Our acne medications truly work best in combination. Topical medications are the cornerstone of acne treatment. If your doctor has recommended a topical medication which you haven’t started, you will likely experience suboptimal improvement. If you can’t afford your entire treatment plan, you can message your doctor asking for the priority of the medications prescribed. 

We encourage you to keep up with your treatment plan and be as consistent as possible. If you don’t see any improvement after two months, you can submit a follow-up visit with your dermatologist at any time. As a reminder, any visit costs are applied to future prescription orders. 


Can I use my other skin care products (such as acne washes, masks, serums, toners) with my treatment plan?

Caret iconBlack upwards facing triangle to reference things above or scroll to the top of page.

Unless a product type is specifically recommended by your dermatologist in your treatment plan, you should avoid using it. While these skincare products may provide incremental benefits for your skin, they can also cause unnecessary irritation. Your prescription medications are much more important and effective. Once you are tolerating your prescription medications easily and your breakouts are under control, you can slowly add your other skincare products back into your routine if you like.


Treat acne with personalized care from home

Circled CheckmarkGray circle outline with white background containing gray checkmark in the center.
Free shipping to your door
Circled CheckmarkGray circle outline with white background containing gray checkmark in the center.
Affordable perscriptions, no insurance needed
Circled CheckmarkGray circle outline with white background containing gray checkmark in the center.
Customized treatment designed by a dermatologist